With destruction of the myelin sheath, progressive deterioration of muscle control and intellectual ability occurs
The treatment team usually involves a neurologist , a pediatrician, an ophthalmologist, an orthopedist, a genetic counselor, a neurodevelopmental psychologist and a genetic and/or metabolic disease specialist
Corynebacterium diphtheriae is an example of a bacterium that contains metachromatic granules. These granules are composed of polyphosphate polymers and are typically observed in the metachromatic staining method where the granules appear blue or purple when stained with methylene blue.
metachromatic granules are polyphosphate granules found in Corynebacterium diphtheriae. They have the property of taking up a stain and exhibiting a different colour - metachromatia. thus they take up malachite green and appear dark blue in colour.
The possible future effects of a problem can vary depending on the specific issue. Common effects can include increased costs, reduced efficiency, damaged reputation, and potential regulatory/legal consequences. Addressing the problem promptly and effectively can help mitigate these future effects.
Pleomorphism, metachromatic granules, and palisade arrangement. Pleomorphism refers to the fact that C. diptheriae is rod-shaped but can appear club-shaped, needle-shaped, or spermlike. Metachromatic granules are reddish-purple granules that are visible when stained with metylene blue. Palisade arrangement refers to the presentation of rods in a parallel fashion that looks like a picket fence.
The juvenile form of metachromatic leukodystrophy is characterized by gait disturbances, urinary incontinence, mental deterioration, and emotional difficulties
Metachromatic leukodystrophy (MLD) is a rare degenerative neurological disease affecting the fatty covering that acts as an insulator around nerve fibers known as the myelin sheath.
Liver and kidney falure.
Adult metachromatic leukodystrophy is characterized by emotional disturbances and psychiatric symptoms. Disorders of movement and posture appear later. Dementia and decreased visual function also occur.
Metachromatic leukodystrophy (MLD), also called sulfatide lipidosis and arylsulfatase A (ARSA) deficiency, is inherited as an autosomal recessive trait, due to mutations in the arylsulfatase A (ARSA) gene
Canavan disease in Ashkenazi Jews, or globoid cell leukodystrophy (GLD) and metachromatic leukodystrophy (MLD) in Scandinavians.
Physical therapists, occupational therapists, orthopedists, ophthalmologists, and neuropsychologists are often involved in helping maintain optimal function for as long as possible.
Death usually results within five years after the onset of clinical symptoms
The infant displays irritability and an unstable walk. As the disease progresses, physical and mental deterioration occur and muscle wasting eventually gives way to spastic movements
In infants neurocognitive function may be stabilized, while persons with the juvenile and adult forms of MLD and with mild symptoms are more likely to be stabilized with bone marrow transplantation
Sulfatide accumulates in the brain and other areas of the body such as the liver, gall bladder, kidneys, and/or spleen. The buildup of sulfatide in the central nervous system causes demyelination
the primary early symptoms are speech difficulties, gait disturbance, behavioral problems, and intellectual decline. The disease progresses rapidly; seizures, blindness, and severe muscle contractions may occur