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The question is a bit vague. There are two main risks: the risk of injury to the experimenter and test subjects, and the risk of erroneous results associated with poor methodology. A great educational program is MythBusters. Although they take some precautions against accidental injury and death, I'm not sure they go quite far enough sometimes, and often their methodolgy leaves much to be desired. But it makes for interesting TV and a lot to talk about!

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