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Clearing reagents are chemicals used in histology and microscopy to remove lipids and other substances from tissue samples, allowing for better penetration of embedding media like paraffin. Common clearing agents include xylene, toluene, and ethanol. These solvents facilitate the transition of tissues from water-based solutions to non-aqueous media, ensuring optimal preservation and visibility of cellular structures. After clearing, tissues can be embedded and sectioned for microscopic examination.

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