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Acetylcholine (ACh) binds to nicotinic receptors on the sarcolemma of muscle fibers, leading to the opening of ion channels. This results in an influx of sodium ions (Na+) into the cell, which depolarizes the sarcolemma and initiates an action potential. The change in ion permeability is crucial for muscle contraction, as it propagates the signal to the interior of the muscle fiber and ultimately stimulates the release of calcium ions from the sarcoplasmic reticulum.
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