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What happens to ACh once it has bound to its receptor?
Once acetylcholine (ACh) binds to its receptor, it can either stimulate or inhibit the activity of the cell. This activation triggers a cellular response, such as muscle contraction or nerve cell communication. After its action, ACh is rapidly broken down by the enzyme acetylcholinesterase to terminate the signal.
What is a cholinomimetic agent?
A drug or compound that acts like acetylcholine (ACh). Acetylcholine is a neurotransmitter. In the peripheral nervous system (PNS), acetylcholine activates muscles. In the central nervous system (CNS), acetylcholine tends to cause decreased muscle contractions. These two responses are opposite. ACh Receptor agonists (booster of the effect) are used to treat myasthenia gravis and Alzheimer's disease. ACh receptor antagonists block muscle contractions causing paralysis. The bite of the Black Widow spider does this.
A deficiency of ACh receptors in a motor end plate would cause and is called?
A deficiency of ACh receptors in a motor end plate would cause muscle weakness or paralysis. This condition is called myasthenia gravis.
How long does receptor activation take?
Receptor activation can happen within milliseconds to seconds when a ligand binds to the receptor, triggering a conformational change. The time it takes for the receptor to fully activate and initiate downstream signaling pathways can vary depending on the specific receptor and the cellular context.
What is the effect of atropine plus acetylcholine on frog heart?
ACh will decrease heart rate/contractile strength, etc. Atropine is a muscarinic ACh receptor (mAChR) antagonist, so blocks the effects of ACh. Adding both together will result in a weak action of ACh that tails off as all the mAChRs become blocked by Atropine.
What happens to ACh once it has bound to its receptor?
Once acetylcholine (ACh) binds to its receptor, it can either stimulate or inhibit the activity of the cell. This activation triggers a cellular response, such as muscle contraction or nerve cell communication. After its action, ACh is rapidly broken down by the enzyme acetylcholinesterase to terminate the signal.
What is a cholinomimetic agent?
A drug or compound that acts like acetylcholine (ACh). Acetylcholine is a neurotransmitter. In the peripheral nervous system (PNS), acetylcholine activates muscles. In the central nervous system (CNS), acetylcholine tends to cause decreased muscle contractions. These two responses are opposite. ACh Receptor agonists (booster of the effect) are used to treat myasthenia gravis and Alzheimer's disease. ACh receptor antagonists block muscle contractions causing paralysis. The bite of the Black Widow spider does this.
Select the option that lists the steps of normal nerve function in the correct order?
ACh is produced at the intercellular level and is stored in vesicles at nerve endings. nerve endings release ACh ACh attavhes to the receptor site at the receiving nerve ACh is broken down by AChE to prevent accumulation
How many air change require for car parking?
as per design NBC 2005 ( 9 to 12 ACH ) 10 ACH can be consider in case of fire 30 ACH to consider
How would you change the pA2 for a drug-receptor pair?
The only way to change the pA2 would be to alter the nature of the receptor, because the pA2 is essentially a measurement of the affinity of the antagonist drug for the receptor. So, in order to change this value, one would need to change the receptor in a way that changes the binding affinity of the drug.
An allosteric receptor embedded in a cell membrane will change shape only?
An allosteric receptor embedded in a cell membrane will change shape in response to the binding of a specific molecule or ligand, which causes a conformational change in the receptor. This change in shape can alter the receptor's ability to interact with other molecules or signaling proteins within the cell, ultimately triggering a cellular response.
What statement describes nicotinic acetylcholine ACh receptors as opposed to muscarinic ACh receptors?
Nicotinic ACh receptors are ionotropic receptors that mediate fast neurotransmission, while muscarinic ACh receptors are metabotropic receptors that modulate cell signaling through G-proteins. Nicotinic receptors are typically found at neuromuscular junctions and in the central nervous system, whereas muscarinic receptors are more widely distributed in peripheral tissues and the brain.
A deficiency of ACh receptors in a motor end plate would cause and is called?
A deficiency of ACh receptors in a motor end plate would cause muscle weakness or paralysis. This condition is called myasthenia gravis.
Why levodopa can cause postural hypotension?
by di receptor stimulation
How long does receptor activation take?
Receptor activation can happen within milliseconds to seconds when a ligand binds to the receptor, triggering a conformational change. The time it takes for the receptor to fully activate and initiate downstream signaling pathways can vary depending on the specific receptor and the cellular context.
How does a transmembrane receptor cause the stimulation of a cell does it take something from the chemokine and feed it through its transversile midsection and into the cell giving it to a transport?
N. Take a G protein linked receptor for an example. The ligand docks and causes a conformational change that causes a G protein to dock with the transmember protein receptor and initiate signal transduction through secondary messengers.
What is the role of the receptor?
The main role of the NMDA receptor in the body is in ensuring neural plasticity. Further research is on-going to further refine understanding of this receptor, and this conclusion may change in future as more studies may find further roles for this receptor.
