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Only isotonic saline (0.9%) is recommended for use with blood components. Other isotonic electrolyte solutions that have been approved by the FDA for this purpose may be used.
Other commonly used intravenous solutions will cause varying degrees of difficulty when mixed with red cells. For example, 5% dextrose in water will hemolyze red cells. Intravenous solutions containing calcium, such as Lactated Ringer's solution, can cause clots to form in blood.

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