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A tight junction appears as a series of interlocking strands that encircle the cell, effectively sealing adjacent epithelial or endothelial cells together. This structure resembles a belt or a band around the cells, preventing the passage of substances between them and maintaining the integrity of tissue barriers. Under an electron microscope, tight junctions are characterized by their close apposition of cell membranes and specialized proteins, such as claudins and occludins, that facilitate their function.

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