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What does the combination mitotic cyclin with CDK signal?
The combination of mitotic cyclin with cyclin-dependent kinase (CDK) signals the cell to enter mitosis, initiating the process of cell division. This complex activates CDK, leading to the phosphorylation of target proteins that promote chromatin condensation, spindle formation, and other key events necessary for mitosis. The precise regulation of this cyclin-CDK complex is crucial for ensuring that the cell divides accurately and at the appropriate time in the cell cycle.
What is the combination of mitotic cyclin with CDK signals the?
The combination of mitotic cyclin (such as cyclin B) with cyclin-dependent kinase (CDK1) signals the onset of mitosis in the cell cycle. This complex activates CDK1 through phosphorylation, leading to critical processes such as chromosome condensation, nuclear envelope breakdown, and spindle assembly. This regulation ensures that the cell is properly prepared to divide, thereby maintaining genomic integrity.
How does cyclin dependent kinase work?
Cyclin dependent kinases (CDKs) are a family of enzymes that regulate cell cycle progression by phosphorylating target proteins involved in cell division. CDK activity is tightly regulated by the binding of cyclins, which activate their kinase function. CDK-cyclin complexes phosphorylate key proteins to drive cell cycle transitions.
What signals signal a cell to divide?
Cells receive signals to divide from various internal and external sources, including growth factors, nutrients, and cell density. These signals activate specific pathways, such as the cyclin-CDK pathway, which regulates the cell cycle progression. Additionally, the presence of adequate space and favorable environmental conditions can also promote division. Ultimately, these signals ensure that cells only divide when conditions are suitable for growth and function.
Increases in the enzymatic activity of some protein kinases important for the regulation of the cell cycle are due to?
phosphorylation by other kinases, which can switch them from an inactive to an active state. This post-translational modification can be triggered in response to specific signals, allowing for precise control of cell cycle progression.
What does the combination mitotic cyclin with CDK signal?
The combination of mitotic cyclin with cyclin-dependent kinase (CDK) signals the cell to enter mitosis, initiating the process of cell division. This complex activates CDK, leading to the phosphorylation of target proteins that promote chromatin condensation, spindle formation, and other key events necessary for mitosis. The precise regulation of this cyclin-CDK complex is crucial for ensuring that the cell divides accurately and at the appropriate time in the cell cycle.
What is the combination of mitotic cyclin with CDK signals the?
The combination of mitotic cyclin (such as cyclin B) with cyclin-dependent kinase (CDK1) signals the onset of mitosis in the cell cycle. This complex activates CDK1 through phosphorylation, leading to critical processes such as chromosome condensation, nuclear envelope breakdown, and spindle assembly. This regulation ensures that the cell is properly prepared to divide, thereby maintaining genomic integrity.
What happens to the Cdk-cyclin A complex at metaphase?
Both cyclin A and Cdk remain undegraded
The initiation of the s phase and the m phase of the sell cycle depends on a pair of biochemicals called?
The initiation of the S phase of the cell cycle depends on cyclin-dependent kinases (CDKs) binding to cyclins. For the M phase of the cell cycle, the activation of the mitotic cyclin-CDK complex is crucial to drive cells into mitosis.
Which of the following is a protein synthesized at specific times during the cell cycle that associates with a kinase to form a catalytically active complex?
Cyclin is a protein synthesized at specific times during the cell cycle that associates with a kinase (CDK) to form a catalytically active complex. Cyclin-CDK complexes regulate the progression of the cell cycle by phosphorylating various target proteins.
What is the family of molecules that control the cell cycle?
cyclin dependent kinases,CDK's
Describe the roles of checkpoint cyclin CDK and MPF in the cell-cycle control system?
Cyclin is a regulatory protein that a kinase much be attached to. Cyclin gets its name from its cyclically fluctuating concentraion in the cell. Because of this requirement, these kinases are called cyclin-dependent kinases, CDK's. The CDK rises and falls with changes in the concentration of its cyclic partner. The first cyclin-CDK complex discovered was the MPF. The peaks of MPF activity correspond to the peaks of cyclin concentration. MPF stands for maturation-promoting factors. Basically, the rhythmic fluctuations in the abundance and activity of cell cycle control molecules pace the sequential events of the cell cycle. These regulatory molecules are proteins; kinase, and other enzymes. Particular protein kinases give the "go-ahead" signals at the G1 and G2 checkpoints.
What is a protein synthesized at specific times during the cell cycle that associates with a kinase to form a catalytically active complex?
Cyclins are proteins that are synthesized at specific times during the cell cycle and associate with cyclin-dependent kinases (CDKs) to form a catalytically active complex. This complex regulates the progression of the cell cycle by phosphorylating specific target proteins.
What is the protein that regulate the timing of the cell cycle in eukaryotic cells known as?
CDK. Cyclin dependent kinases.
How does cyclin dependent kinase work?
Cyclin dependent kinases (CDKs) are a family of enzymes that regulate cell cycle progression by phosphorylating target proteins involved in cell division. CDK activity is tightly regulated by the binding of cyclins, which activate their kinase function. CDK-cyclin complexes phosphorylate key proteins to drive cell cycle transitions.
What is the protein that regulates cell cycle?
The protein that regulates the cell cycle is called cyclin-dependent kinase (CDK). CDK is activated by binding to specific proteins called cyclins at different stages of the cell cycle. Together, CDK and cyclin complexes regulate the progression of the cell cycle by phosphorylating target proteins that control cell division.
Which cyclin forms the primary Cdkc that controls the G2 stage?
Cyclin B forms the primary Cyclin-dependent kinase complex (Cdkc) that controls the G2 stage of the cell cycle. Cyclin B-Cdk complex plays a crucial role in regulating the progression from the G2 phase to mitosis by phosphorylating specific target proteins.
