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Ionic compounds can significantly affect cellular membranes by altering their permeability and fluidity. When ions such as sodium, potassium, or calcium enter or leave the cell, they can change the membrane potential, influencing cellular signaling and function. High concentrations of certain ions can lead to membrane disruption, affecting cellular integrity and potentially causing cell death. Additionally, ionic imbalances can interfere with transport mechanisms and enzymatic activities within the cell.

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The resting membrane potential is primarily established by the Na⁺/K⁺ pump and the selective permeability of the membrane to ions, particularly K⁺. The Na⁺/K⁺ pump actively transports three Na⁺ ions out of the cell and two K⁺ ions into the cell, contributing to a negative charge inside the cell. The Donnan effect, which describes the distribution of ions across a membrane due to the presence of impermeant solutes, plays a role in influencing ion concentrations but is not the primary determinant of resting membrane potential. Thus, while both mechanisms are involved in cellular ion balance, the Na⁺/K⁺ pump is the key player in setting the resting membrane potential.


What has the author s Hagiwara written?

s. Hagiwara has written: 'Membrane potential-dependent ion channels in cell membrane' -- subject(s): Cell Membrane, Cell membranes, Ion channels, Ion exchange, Ion-permeable membranes, Membrane Potentials, Physiology


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