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The body's cells need to be isotonic to blood plasma to prevent too much osmosis of water either into or out of the cells. The kidneys are the main organs controlling this. If you exercise in hot weather without drinking enough water, you perspire heavily and so you lose water from your body. Your blood plasma becomes hypertonic to your cells and your kidneys will remove less water from the blood plasma, meaning that urine becomes less in quantity and higher in concentration of other materials, especially urea and uric acid.

If you drink a lot of water in a cooler environment while resting, the plasma will become hypotonic to the body's cells. In that case, the urine will be more plentiful and more dilute because the kidneys will pull more water out of the blood to try to maintain isotonicity in the body.

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