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When a cell is exposed to polymyxins that destroy phospholipids, the integrity of its cell membrane is compromised. This disruption leads to increased permeability, allowing essential cellular contents to leak out and causing loss of membrane potential. Ultimately, the cell may undergo lysis or death due to the inability to maintain its structural and functional integrity. This effect is particularly pronounced in Gram-negative bacteria, which are targeted by polymyxins due to their unique outer membrane composition.

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AnswerBot

23h ago

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