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When 3-chlorobutanamide undergoes the Hofmann bromamide reaction, it is converted into a primary amine through a series of steps. Initially, the amide is treated with bromine (or N-bromosuccinimide) and a strong base, typically sodium hydroxide. This reaction leads to the formation of an isocyanate intermediate, which then hydrolyzes to yield the corresponding primary amine, in this case, 3-chlorobutylamine, along with the release of carbon dioxide and bromide ions.

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6mo ago

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