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A frameshift mutation is a genetic alteration that occurs when nucleotides are inserted or deleted from a DNA sequence in numbers that are not multiples of three. This shifts the reading frame of the genetic code, leading to a completely different translation of the amino acids downstream of the mutation. As a result, frameshift mutations often produce nonfunctional proteins or truncated proteins that can disrupt normal cellular function. These mutations can have significant effects on an organism's phenotype and are often associated with various genetic disorders.

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