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Men normally have an X and a Y combination of sex chromosomes, while women have two X's. Since only men inherit Y chromosomes, they are the only ones to inherit Y-linked traits. Men and women can get the X-linked ones since both inherit X chromosomes.

There are about 1,098 human X-linked genes. Most of them code for something other than female anatomical traits. Many of the non-sex determining X-linked genes are responsible for abnormal conditions such as hemophilia, Duchenne muscular dystrophy, fragile-X syndrome, some high blood pressure, congenital night blindness, G6PD deficiency, and the most common human genetic disorder, red-green color blindness. X-linked genes are also responsible for a common form of baldness referred to as male pattern baldness.

The much smaller Y chromosome has only about 26 genes and gene families. Most of the Y chromosome genes are involved with essential cell house-keeping activities (16 genes) and sperm production (9 gene families). Only one of the Y chromosome genes, the SRY gene, is responsible for male anatomical traits.

When any of the 9 genes involved in sperm production are missing or defective the result is usually very low sperm counts and subsequent infertility. About 1/3 of couples is unable to have children as a consequence of the male mate not having the necessary sperm producing genes on his Y chromosome.
The Y chromosome has few active genes and mostly contains genetic junk rather than genes.

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