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What is arsenolysis?

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∙ 11y ago
Updated: 10/16/2024

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Arsenate acts as uncoupling agent for oxidative phosphorylation?

Yes. During glycolysis, arsenate which has a similar structure to phosphate replaces it from glyceraldehyde-3-phosphate to form an unstable arsenate anhydride( 1-arsenato-3-phospho-d-glycerate) that hydrolyzes to form arsenate and 3-phosphoglycerate. In the absence of phosphate, ATP is not formed in the reaction. ADP-arsenate is formed from ADP and arsenate in the presence of succinate. The formation of easily hydrolyzable ADP-arsenate complex uncouples oxidative phosphorylation and causes arsenolysis.


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