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Erythropoiesis is the process by which red blood cells (erythrocytes) are produced. In human adults, this usually occurs within the bone marrow.

In humans with certain diseases and in some animals, erythropoeiesis also occurs outside the bone marrow, within the spleen or liver. This is termed extramedullary erythropoiesis.

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What is ineffective erythropoiesis?

Ineffective Erythropoiesis as described by Goljan's Rapid Review in Pathology:RBC's with alpha-chain inclusions undergo apoptosis in the bone marrow. You can see why the term is as such because RBCs are damaged/apoptosed/removed prior to release, resulting in 'ineffective' erythropoiesis.Ineffective erythropoiesis is the active erythropoiesis with premature death of created red blood cells RBCs, a decreased output of red blood cells from the bone marrow and consequently anemia.


What is process by which red blood cells are produced this process take place in the what?

erythropoiesis bone marrow


What would cause increased erythropoiesis?

Increased erythropoiesis can be stimulated by conditions like hypoxia (low oxygen levels), anemia, high altitude, chronic kidney disease, or certain medications like erythropoietin. These conditions trigger the release of erythropoietin, a hormone that stimulates the production of red blood cells in the bone marrow.


What part of the body does erythropoietin (EPO) target to increase erythropoiesis?

Erythropoietin (EPO) primarily targets the bone marrow to increase erythropoiesis, which is the production of red blood cells. It stimulates the differentiation of progenitor cells into erythrocytes and promotes their maturation. EPO is produced mainly by the kidneys in response to low oxygen levels in the blood.


What is the role of b12 in erythrogenesis?

Vitamin B12 plays a crucial role in erythropoiesis by supporting the maturation of red blood cells in the bone marrow. It is involved in the synthesis of DNA, which is essential for the production of red blood cells. A deficiency in vitamin B12 can lead to impaired erythropoiesis and result in a type of anemia known as megaloblastic anemia.

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