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The f1 and f2 factors are metrics used to assess the similarity between two dissolution profiles in pharmaceutical studies. The f1 factor (dissimilarity) quantifies the percentage difference between the two profiles, while the f2 factor (similarity) measures the logarithmic mean of the absolute differences between the two profiles. An f2 value greater than 50 typically indicates that the profiles are similar, while f1 values closer to zero suggest similarity. These factors help in evaluating the bioequivalence of drug formulations.

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