What is linkage disequilibrium?

Answer 1

Linkage disequilibrium is the non-random association of alleles at two or more loci. It is broken down by recombination. Linkage equilibrium = independence between allele frequencies at two different SNPs Linkage disequilibrium = Association between alleles at different SNPs (SNPs are Single Nucleotide Polymorphism - Pronounced snips)

Answer 2

Linkage is the physical proximity of the genes. LD or Linkage disequilibrium is the non random association of the genotype / alleles. The genes contributing to the trait in the case of LD can be physically apart from each other ( sometimes even on different chromosomes )

linkage disequilibrium is the non-random association of alleles at two or more loci, not necessarily on the same chromosome. It is not the same as linkage, which describes the association of two or more loci on a chromosome with limited recombination between them. Linkage disequilibrium describes a situation in which some combinations of alleles or genetic markers occur more or less frequently in a population than would be expected from a random formation of haplotypes from alleles based on their frequencies. Non-random associations between polymorphisms at different loci are measured by the degree of linkage disequilibrium (LD).

Linkage disequilibrium is generally caused by genetic linkage and the rate of recombination; rate of mutation; random drift or non-random mating; and population structure. For example, some organisms (such as bacteria) may show linkage disequilibrium because they reproduce asexually and there is no recombination to break down the linkage disequilibrium.

Answer 3

A pairwise linkage disequilibrium diagram is a triangular graphical representation of linkage disequilibrium in which different colours represent different magnitudes of linkage between pairs of loci.

Answer 4

Linkage disequilibrium is the non-random association of genetic variants on the same chromosome, often due to being inherited together without recombination occurring frequently. It can provide information about the genetic architecture and evolutionary history of a population. High levels of linkage disequilibrium can impact genetic association studies by affecting the interpretation of genetic markers.