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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate properly during cell division, specifically in meiosis or mitosis. This results in gametes or daughter cells with an abnormal number of chromosomes, leading to conditions such as Down syndrome, Turner syndrome, or Klinefelter syndrome when these gametes participate in fertilization. Nondisjunction can occur in any organism and can have significant genetic implications.
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