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Receptors generate a cellular response upon binding their specific ligand. This response can vary in magnitude. Desensitisation is a phenomenon in which activation of a receptor can reduce the magnitude of the response if it is subsequently activated again. Usually the longer a receptor is activated for the greater the desensitisation will be.

There are 3 general mechanisms as to how desensitisation occurs. The first is uncoupling of the receptor from proteins which generate the cellular response. The second is internalising receptors so that they cannot be activated. The third is reducing production of receptors so less are available. In general mechanism 1 is short term, 2 is mid-term and 3 is long term.

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