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Subtractive genomic strategy is developed by assuming that the novel targets identified in the pathogen should be essential for the pathogen that is it should be involved in the replication, survival and a important component

of various metabolic pathways and mechanisms occurring in the pathogen while at the same time should be absent on the host that is human and should have no homologue in human, so that when a drug or a lead compound is designed considering the potential target it should only be against the mechanism and functionality of the pathogen not the host.

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13y ago

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