answersLogoWhite

0

I am answering my own question here I'm afraid, but I have since found the answer.

Basically, a checkpoint (otherwise known as the DNA damage checkpoint) response is a stage in DNA replication where the cell cycle stops owing to DNA damage and becomes more susceptible to apoptosis ( programmed cell death). a more detailed answer is shown in the paragraph below.

"In response to DNA damage, eukaryotic cells activate a set of surveillance systems that interrupt cell cycle progression to allow time for repair. These surveillance systems are called checkpoints and have been given an empirical definition. The DNA damage checkpoint acts in three stages in the cell cycle, one at the G1-S phase transition (G1 checkpoint), one at S phase (S-phase checkpoint), and one at the G2-M boundary (G2 checkpoint. With checkpoint failure, the immediate consequence is that the cells increase their sensitivity to being killed, and the long-term consequence is that the cells increase their susceptibility to tumor genesis. S-phase checkpoint monitors progression through S phase, which slows the rate of on-going DNA synthesis."

Ref: http://cancerres.aacrjournals.org/cgi/content/full/62/6/1598

User Avatar

Wiki User

17y ago

What else can I help you with?

Continue Learning about Natural Sciences
Related Questions

At the DNA synthesis G2 checkpoint DNA replication is checked by 1 receptor proteins 2 Repair enzymes 3 electron transport chains 4 cell surface markers?

2 Repair enzymes. At the DNA synthesis G2 checkpoint, DNA replication is checked by repair enzymes that detect and repair any mistakes in the replicated DNA before the cell progresses to mitosis. Receptor proteins, electron transport chains, and cell surface markers are not directly involved in checking DNA replication at this checkpoint.


Where is the checkpoint for DNA damage?

g1


Which phase do DNA synthesis occur?

Actually, DNA synthesis occurs in the interphase stage, after the G1 checkpoint and before the G2 checkpoint, in the synthesis period, sometimes referred to as the 'S' phase, though it is not in fact a phase of mitosis, but rather a part of the Interphase as a whole. I hope this is more helpful than the previous answer of; "nobody knows IDIOT."


Another term for DNA synthesis?

DNA synthesis is also known as DNA replication.


What is the DNA process?

DNA synthesis or DNA replication


When DNA cynthesis occures?

Within the Cell cycle, Dna synthesis occurs during the S [synthesis] phase.


When does a cell make sure DNA has been copied correctly before continuing in the cell cycle?

DNA is copied (or replicated) by an enzyme called DNA polymerase. This enzyme generally operates in the 3' to 5' direction. However, this enzyme also has a 5' to 3' exonuclease activity, which enables it to remove certain wrong bases and insert correct ones. This ensure that the DNA is copied correctly


How would prevention of DNA synthesis affect mitosis?

There would not be enough DNA to put in daughter cells, since DNA synthesis is the replication of DNA.


What is made after the enzyme passes the end of the DNA?

After the enzyme passes the end of the DNA, the replication process is completed with the synthesis of a short RNA primer that is later replaced with DNA nucleotides by another enzyme called DNA polymerase. This results in the completion of a full DNA strand.


When does a cell move into the G2 checkpoint?

A cell moves into the G2 checkpoint after completing the S phase of the cell cycle, where DNA replication occurs. The G2 checkpoint ensures that the cell has accurately replicated its DNA before entering the mitotic phase.


Which number represents DNA synthesis?

DNA synthesis is represented by the S phase of the cell cycle.


What requires DNA synthesis?

DNA replication, repair, and recombination all require DNA synthesis. These processes involve enzymes that copy existing DNA strands to produce new DNA molecules. Additionally, DNA synthesis is necessary for cell division and growth.