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to reduce to particles, fragments, or parts; break up ordestroy the cohesion of: Rocks are disintegrated by frost andrain.

Tablets or capsules taken orally remain one of the most effective means of treatment available. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet or capsule is therefore crucial.

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What is the difference between dissolution and disintegration in capsule and tablet?

Dissolution is the process by which a drug substance dissolves in a liquid medium, such as gastric fluid, to become available for absorption. Disintegration, on the other hand, refers to the breaking apart of the tablet or capsule into smaller particles. Disintegration occurs first to increase the surface area for dissolution to happen efficiently.


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