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Euglena, Paramecium and Amoeba are all monocellular organisms. The major difference lies in their mode locomotion. The amoeba moves with the help of its pseudopodia, that are temporary protrusions of cytoplasm, giving leg like appearance. In paramecium, there are small outgrowths that are called as Cilia (Sing. Cilium). These cilia are thousands in number and are present all over the cells' surface. They act like an oar. Finally, Euglena have Flagellum (plur. flagella). A flagella beats like a whip to provide driving force for the movement.

Apart from this, both Euglena and Paramecium have a fixed body shape but amoeba continuously keeps on changing its shape . Amoeba and Paramecium are heterotrophic and lack chloroplast while Eugena has chloroplasts and could synthesise its own food. Amoeba and Euglena are monokaryotic ( One nucleus only) while paramecium has two nuclei and is dikaryotic.

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