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Neurofibromatosis 1

hyperpigmented macules (cafe au lait spots)

nerve tumors

types: cutaneous, subcutaneous and plexiform neurofibromas

Optical tumors

optic pathway gliomas and

Lisch nodules (bumps on iris of the eye)

Bony abnomralities

dysplasias (malformations) of the eye socket, vertebrae

Thinning of the long bone cortex

Scoliosis can occur as well

learning deficits

yet large head size

Increased rick of non nervous system cancers

Neurofibromatosis 2

generally just schwannomas, meningomas

and the occasional cataracts.

Also they are both affected by different chromosomes... patients with NF1 has a mutation on the long arm of chromosome 17 while neurofibromatosis 2 has a mutation on chromosome 22.

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