What is the difference between peripheral and integral proteins?

Answer 1

Peripheral proteins are under the phospholipid bilayer, while integral proteins are inscribed in the bilayer.
Integral proteins pass entirely through the lipid bilayer of the plasma membrane and have domains that go from the outside of the cell to the cytoplasm inside the cell. While peripheral proteins are only on the one side of the lipid bilayer, either the outside of the cell or the cytoplasmic side inside the cell, but not both.

Answer 2

Peripheral proteins are loosely attached to the membrane surface, often through electrostatic interactions with the phospholipid heads or other membrane proteins. Integral proteins are embedded within the lipid bilayer, with regions that extend into both the extracellular and cytoplasmic sides of the membrane. Integral proteins are typically involved in transporting molecules across the membrane or serving as receptors, while peripheral proteins are more involved in signaling and cell recognition.

Answer 3

Peripheral proteins are attached outside the lipid bilayer of the cell membrane and are easily detached. Integral proteins are attached inside the lipid bilayer and cannot easily be removed.

Answer 4

Integral membrane protein is inside the lipid bilayer. Whereas peripheral protein is attached to the integral protein or attached to the hydrophilic heads of the bilayer.

Answer 5

Peripheral provides the frame work for the plasma membrane and is attached to integral protein. Integral goes through the membrane with two hydrophilic ends.