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What is the dissolution method for atorvastatin tablets if you want to analyze by uv spectroscopy?
the best conditions for atorvastatin calcium 10 mg tablets is as the following dissolution media is 0.05 potassium dihydrogen phosphate buffer PH is 6.8 use paddle II 75 rpm for 45 min make standard dilution in the same media and max abs. is almost at 243 nm for higher conc of atorvastatin use sodium lauryl sulphate 0.5 %
What else can I help you with?
Why using 6 tablets for dissolution tester?
Using 6 tablets in a dissolution tester allows for statistical analysis and ensures reproducibility of the results. By testing multiple tablets, we can account for variability between tablets in a batch, providing a more accurate representation of the overall dissolution profile of the drug product. It also helps in assessing the consistency of tablet performance across the batch.
Why calcium carbonate added in a Atorvastatin calcium tablet?
Calcium carbonate is added to Atorvastatin calcium tablets as a buffering agent to help stabilize the pH of the tablet formulation. This helps ensure the drug remains stable and active throughout its shelf life. Additionally, calcium carbonate can aid in the absorption of Atorvastatin in the body.
Vitamins to analyze the variation of vitamin supplement tablets you randomly select and weigh 14 tablets the results in milligrams are shown use 90 percent level of confidence?
To analyze the variation of vitamin supplement tablets, calculate the mean and standard deviation of the weights of the 14 tablets. With a 90% confidence level, determine the margin of error using the t-distribution. This margin of error will help define the range within which the true mean weight of the tablets is likely to lie.
Are Antacid tablets soluble?
This is because the surface area of the tablet is increased.
Why do akla seltzer tablets dissolve faster in hot water?
Alka-Seltzer tablets dissolve faster in hot water because the heat increases the kinetic energy of the water molecules, causing them to move faster and collide with the tablets more frequently, breaking them down at a quicker rate. This leads to a faster dissolution of the tablet's ingredients into the water.
Why use 6 tablets for dissolution test?
i dont no
Why using 6 tablets for dissolution tester?
Using 6 tablets in a dissolution tester allows for statistical analysis and ensures reproducibility of the results. By testing multiple tablets, we can account for variability between tablets in a batch, providing a more accurate representation of the overall dissolution profile of the drug product. It also helps in assessing the consistency of tablet performance across the batch.
Why calcium carbonate added in a Atorvastatin calcium tablet?
Calcium carbonate is added to Atorvastatin calcium tablets as a buffering agent to help stabilize the pH of the tablet formulation. This helps ensure the drug remains stable and active throughout its shelf life. Additionally, calcium carbonate can aid in the absorption of Atorvastatin in the body.
Dissolution limits for Vitamin D3 SR tablets?
The dissolution limits for Vitamin D3 SR tablets are typically set at 80-100% within 45-60 minutes using a suitable dissolution medium and apparatus as per pharmacopeial guidelines. The release profile should ensure adequate bioavailability and sustained release characteristics over a specified time period. Manufacturing protocols and quality control measures should be strictly followed to maintain the desired dissolution limits.
Why only Prednisone tablet use in calibration of dissolution test?
coz Prednisone tablets are very sensitive to dissolved gasses.
Vitamins to analyze the variation of vitamin supplement tablets you randomly select and weigh 14 tablets the results in milligrams are shown use 90 percent level of confidence?
To analyze the variation of vitamin supplement tablets, calculate the mean and standard deviation of the weights of the 14 tablets. With a 90% confidence level, determine the margin of error using the t-distribution. This margin of error will help define the range within which the true mean weight of the tablets is likely to lie.
Why does a alka seltzer tablet in power form dissolve faster in surface water then in tablet form?
Alka-seltzer tablets dissolve faster in powder form because the increased surface area of the powder allows for more contact with the water, speeding up the dissolution process. In contrast, tablets have a smaller surface area exposed to the water, resulting in a slower dissolution rate.
Are Antacid tablets soluble?
This is because the surface area of the tablet is increased.
Types of dissolution appratus used for drug dissolution?
The two common types of dissolution apparatus used for drug dissolution testing are the USP apparatus I (basket) and USP apparatus II (paddle). The basket apparatus is recommended for capsules and floating dosage forms, while the paddle apparatus is typically used for tablets and other solid dosage forms. Both apparatus are designed to simulate the conditions of the gastrointestinal tract to assess drug release characteristics.
When basket is use in dissolution method?
Baskets are commonly used in the dissolution method in pharmaceutical analysis to hold the dosage forms being tested, such as tablets or capsules. The basket allows for uniform immersion of the dosage form in the dissolution medium, ensuring accurate and consistent results in determining drug release rates. It also provides a barrier to prevent disintegration or breakage of the dosage form during testing.
Why do akla seltzer tablets dissolve faster in hot water?
Alka-Seltzer tablets dissolve faster in hot water because the heat increases the kinetic energy of the water molecules, causing them to move faster and collide with the tablets more frequently, breaking them down at a quicker rate. This leads to a faster dissolution of the tablet's ingredients into the water.
Does tablets or capsules dissolves first?
In fact, dissolution depends upon nature of individual molecule contained in tab. or cap. their form of preprn. does not therapeutically matter. generally bitter molecules are contained in capsule.
