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Mitochondria are significant to a cell because they are the site of aerobic cellular respiration. In the cytoplasm, glucose is converted anaerobically into pyruvate. The pyruvate enters the mitochondrion, where a series of reactions called the Krebs cycle breaks it down to carbon dioxide and water. A summary of this pyruvate breakdown is: C3H4O3 → 3CO2+ 3H2O During this process, energy is released as bonds of organic molecules are broken. At some stages, energy is released in large enough packets to drive the synthesis of ATP: ADP + Pi → ATP [Pi= an inorganic phosphate ion] For the individual reactions of the Krebs cycle, visit: http://en.wikipedia.org/wiki/Krebs_cycle

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