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The gap between membrane-spanning proteins is often referred to as the "intermembrane space" or "extracellular space," depending on the context. This gap can vary in width and serves as a region for signaling, ion transport, or molecular interactions. In some cases, such as in ion channels or transporters, the gap may allow specific molecules to pass through or interact with the interior of the cell or the surrounding environment. The specific functions and dimensions of this gap can vary significantly between different types of membrane proteins.

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