What is the specific chromosome affected for cleft lip?

Answer 1

? The human geneticists from the University of Bonn had examined the DNA of 460 persons with clefts. More than half of them were examined more closely. The scientists analysed more than 500,000 items of information from their DNA and then compared these with the genetic snippets of a control group. A specific area in the human genome caught the scientists' attention. 'This was a point on the long arm of chromosome 8, where the cleft group conspicuously often had a variant, far more frequently than people who had no abnormality,' Dr. Elisabeth Mangold, a lecturer from the Institute of Human Genetics at the University of Bonn, explains. This is a notable clue that a gene located in this region has something to do with the occurrence of clefts

Answer 2

Cleft lip can be caused by a variety of genetic and environmental factors. In some cases, it can be associated with specific chromosomal abnormalities, such as deletions in chromosome 22q11.2 or changes in chromosome 8. However, cleft lip is typically a complex trait influenced by multiple genes and environmental factors.