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Every element provides a couple of isotopes which are of very different use.

For example, carbon has a radioactive isotope (14C).

You can, for example, grow bacteria on a modified substrate which contains the radioactive isotope instead of normal carbon.

The resulting generation will inherit carbon in it's cellular substance which is not only heavier (14 instead of 12 nucleons) but also emits measurable radiation.

These features can be used to reconstruate cellular growth processes, as well as in other organisms bodily functions and development.

Hydrogen has three isotopes, one of them deuterium (features one neutron), which makes it twice as heavy as normal hydrogen. D2O water is therefore much heavier than normal H2O water. As water is widely used in most metabolic pathways, "marking" with D2O can let you find the isotope in different parts of the organism and it's products. For example, a plant can be fed with D2O, afterwards you can see how much of it was metabolized and used for building biological substance, and how much of it was transpirated through the leaves.

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