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To increase the rate of lipolysis, hormonal signals such as epinephrine and norepinephrine must activate lipase enzymes in fat cells to break down stored triglycerides into fatty acids and glycerol. This process is triggered by factors like exercise, fasting, and low insulin levels, which promote the release of stored fat for energy. Additionally, maintaining a calorie deficit and consuming a diet high in protein and low in refined carbohydrates can also stimulate lipolysis.

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