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Bumetanide is a drug that affects the kidneys (specifically the NaCl/KCl cotransporter in the thick ascending loop of Henle).  The drug is a diuretic used mainly to treat hypertension: it disables the NaCl/KCl cotransporter, sodium remains in the lumen, and water follows the sodium out of the body.  An important side effect of the drug is that it also tends to cause potassium wasting (hypokalemia).

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15y ago

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