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The plasma membrane surrounding animal cells is where the exchange of substances inside and outside of cells takes place. Some substances need to move from the extracellular fluid outside cells to the inside of the cell, and some substances need to move from the inside of the cell to the extracellular fluid.

Some of the proteins that are stuck in the plasma membrane help to form openings (channels) in the membrane. Through these channels, some substances such as hormones or ions are allowed to pass through. They either are "recognized" by a receptor (a protein molecule) within the cell membrane, or they attach to a carrier molecule, which is allowed through the channels. Because the plasma membrane is choosy about what substances can pass through it, it is said to be selectively permeable.

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