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Premarin doesn't come from a plant. It's made from the urine of pregnant mares (female horses). The name Premarin comes from the source of the estrogen-- PREgnant MAres' uRINe.

A mare is pregnant for 10 months. Beginning in the fourth month, the mare is placed in a small stall, just large enough for her to step forward and back one step, and just wide enough for her to shift slightly from side to side. She is hooked up to a urine collection device for 20-22 hours a day. In order to concentrate the urine and provide a higher level of collected estrogen, her water intake is restricted. This is her living arrangement for the remaining 6 months of her pregnancy.

Mares are kept in production, foaling every year, for eight to nine years. When no longer able to reproduce, they are sold for slaughter. Under normal circumstances, a domestic equine will live 20 to 25 years.

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12y ago

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