What triggers the cell's passage from G2 checkpoint into mitosis?

Answer 1

Cells go through a cycle that has several distinct stages, called

M (for mitosis), G1 (first Gap or Growth stage), S (for DNA synthesis)

and G2 (second gap). The decision to divide is made during G1 stage,

when the cell "senses" that its growth conditions or status is OK to

divide. The real signal is not entirely clear yet; there are probably

several such signals that get integrated together to make the decision.

We are learning a lot about the machinery that then gets things moving;

I can supply more details if you wish. Once the decision in G1 is made

the rest of the cell cycle proceeds more or less like clockwork; 6-8 hours

for DNA synthesis, a few hours in G2 (to get ready to divide), and an

hour or so in Mitosis itself. Totally not mine, just trying to help.

Answer 2

The activation of cyclin-dependent kinase (CDK) and the degradation of cyclin B trigger the cell's passage from the G2 checkpoint into mitosis. These events cause the activation of the mitotic promoting factor (MPF), which initiates the process of mitosis in the cell.

Answer 3

You need cyclin A to degrade and an increase in cyclin B/CdK1 in an inactive/phosphrylated form.

Answer 4

After A cell splits and 1 of the 2 daughter cells grow, the cell goes into Interphase. After Interphase is Anaphase, which is the start of mitosis.

Answer 5

Sufficient amount of mpf has to build up

Answer 6

MPF

Answer 7

MPF!