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The Nucleus Accumbens and Substantia Nigra both play a very important role in addiction; however, the Ventral Tegmental Area is also closely associated with addiction. The Amygdala, and the Hippocampus are also important to consider in addiction. Addiction is related to the mesolimbic dopamine pathway, which is responsible for motivation, as well as feelings of reward and reinforcement for behavior, and includes the NAcc, VTA, Amygdala, and Hippocampus.

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