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Helicases must break the hydrogen bonds between paired nucleotide bases (Thymidine-Adenosine or Guanosine-Cytosine) of DNA strands so the two strands can be separated and replicated.
The origins of replication, the initial "replication bubbles", tend to be in sequences that are A-T rich because Adenine-Thymidine has only two hydrogen bonds, energetically easier for helicases to start breaking than the three hydrogen bonds between Guanosine-Cytosine.
For replication to continue topoisomerases must also cut the phosphate backbones of DNA strands, otherwise the helically wrapped strands would get much too overwound or "supercoiled" for polymerases and related replication machinery to continue to function.
Nucleosomes (complexes of histone proteins that DNA wraps around) also have to be rearranged or removed to allow for replication.
What else can I help you with?
What happens first in DNA replication?
base pairs are broken apart
What is the name of the simple sugar whose chemical formula is C6H12O6 is broken down during glycolysis?
The simple sugar with the chemical formula C6H12O6 is glucose. Glucose is broken down during glycolysis, which is the first step in cellular respiration, to produce energy in the form of ATP.
Which step happens first in DNA replication A.Protein is formed from the DNA. B.The DNA is checked for errors. C.The replication fork forms. D.Base pairs are broken apart.?
The first step in DNA replication is D. Base pairs are broken apart. This occurs when the double helix unwinds and the hydrogen bonds between the complementary base pairs are broken, allowing the strands to separate. This separation creates a replication fork, setting the stage for the synthesis of new DNA strands.
What decision is made during the first checkpoint in the cell cycle?
At the first checkpoint of the cell cycle, the cell has to ascertain whether it has all the nutrients and chemical compounds necessary for the next phase, which is Synthesis phase, which is predominated by DNA replication. Replication is a resource-intensive process and so the cell has to ensure it has sufficient building materials for the entire DNA to be replicated, that is, ribose sugar molecules, the nitrogen bases, sufficient ATP producing capability by it's mitochondria to allow the addition of each nucleotide. All this has to be accounted for before the cell can proceed with the process of replication. Besides replication, it also has to ensure all other organelles are also in sufficient number or duplicated for the inevitable cytokinesis during mitosis.
What is the helicase enzyme?
Helicase is an enzyme that plays a critical role in DNA replication by unwinding the double-stranded DNA helix into two separate strands. This process is necessary for DNA polymerase to access the DNA template and synthesize new strands during replication.
What type of chemical bond is broken during the first step of replication a. ionic b. hydrogen c. covalent d. peptide?
The chemical bond broken during the first step of replication is hydrogen bond (b).
What happens first in DNA replication?
base pairs are broken apart
Which happens first in DNA replication?
(Apex) Base pairs are broken apart.
What is the name of the simple sugar whose chemical formula is C6H12O6 is broken down during glycolysis?
The simple sugar with the chemical formula C6H12O6 is glucose. Glucose is broken down during glycolysis, which is the first step in cellular respiration, to produce energy in the form of ATP.
Which step happens first in DNA replication A.Protein is formed from the DNA. B.The DNA is checked for errors. C.The replication fork forms. D.Base pairs are broken apart.?
The first step in DNA replication is D. Base pairs are broken apart. This occurs when the double helix unwinds and the hydrogen bonds between the complementary base pairs are broken, allowing the strands to separate. This separation creates a replication fork, setting the stage for the synthesis of new DNA strands.
What molecule is first active during DNA replication?
helicase enzymes
What is the first event to occur during DNA replication?
DNA replication occurs during mitosis and meiosis. During this process, the DNA is lined up before being duplicated so that each cell that's created from the process has the DNA needed.
Which is the first step to occur during the process of replication?
The first step in the process of replication is the unwinding of the DNA double helix by an enzyme called helicase. This process separates the two strands of DNA, creating a replication fork where new nucleotides can be added to each strand.
What kinds of bonds are broken between N-bases when DNA unzips during replication?
During DNA replication, the bonds broken between N-bases are hydrogen bonds. These hydrogen bonds are relatively weak compared to the covalent bonds that hold the sugar-phosphate backbone together. The breaking of hydrogen bonds allows the two strands of the DNA double helix to separate, providing access for DNA polymerase to create new complementary strands.
What happens to the bonds of substance during a chemical reaction?
First chemicals bonds in the starting substances must break. Molecules are always moving. If the molecules bump into each other with enough energy,the chemical bonds in the molecules break. ;)
What decision is made during the first checkpoint in the cell cycle?
At the first checkpoint of the cell cycle, the cell has to ascertain whether it has all the nutrients and chemical compounds necessary for the next phase, which is Synthesis phase, which is predominated by DNA replication. Replication is a resource-intensive process and so the cell has to ensure it has sufficient building materials for the entire DNA to be replicated, that is, ribose sugar molecules, the nitrogen bases, sufficient ATP producing capability by it's mitochondria to allow the addition of each nucleotide. All this has to be accounted for before the cell can proceed with the process of replication. Besides replication, it also has to ensure all other organelles are also in sufficient number or duplicated for the inevitable cytokinesis during mitosis.
Is DNA replicated during G1?
Yes. Cell division refers to mitosis or meiosis.DNA replication occurs before every division for mitosis.In meiosis there are 2 separate cell divisions, and the DNA only replicates before the first one.
