Induced pluripotent stem cells (iPSCs) were first generated in 2006 by Shinya Yamanaka and his team. However, the approval for clinical applications of iPSCs has occurred more gradually, with significant milestones including the first clinical trial using iPSCs for age-related macular degeneration approved in Japan in 2014. The field continues to evolve, with various applications and approvals developing in subsequent years.
An advantage of using pluripotent cells over multipotent cells is their ability to differentiate into any cell type in the body, providing a wider range of potential applications in regenerative medicine and tissue engineering. Pluripotent cells, such as embryonic stem cells or induced pluripotent stem cells, can generate various specialized cells, enabling researchers to study diseases, develop drugs, and create personalized therapies. In contrast, multipotent cells are limited to differentiating into a specific line of cells, which restricts their versatility in therapeutic applications.
Pluripotent cell can differentiate into almost any type of cell.
Pluripotent cells can differentiate into almost any type of cell.
Induced pluripotent stem cells (iPSCs) are created by reprogramming somatic cells, such as skin or blood cells, to a pluripotent state. This is typically achieved by introducing specific transcription factors, often using viral vectors, which activate genes associated with stem cell properties. The reprogrammed cells can then differentiate into various cell types, similar to embryonic stem cells. This process allows for the generation of patient-specific stem cells for research and therapeutic applications.
They are not pluripotent.(APEX)
Pluripotent cells can differentiate into more types of cells.
Pluripotent cells can differentiate into more types of cells.
Pluripotent cell can differentiate into almost any type of cell.
Pluripotent cells can differentiate into almost any type of cell.
Pluripotent cells can differentiate into almost any type of cell.
Pluripotent cells can differentiate into almost any type of cell.
Pluripotent cells can differentiate into almost any type of cell.
Pluripotent cells can differentiate into almost any type of cell.
Pluripotent cells can differentiate into almost any type of cell.
They are not pluripotent.
They are not pluripotent.(APEX)
They are not pluripotent.(APEX)