That depends on what kind of reaction system you have. Generally, large CSTRs are not suited for use at high pressures because of mechanical strength limitations. Typically, they are used for liquid phase reaction systems at low or medium pressures when appreciable residence times are required. PFRs are more suitable at higher pressures and temperatures. The PFR are usally employed for liquid phase reactions when relatively short residence times are needed. It is the reactor of choice for continuous gas phase operations. Hope that helps.