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The signal to excite a muscle cell must cross the neuromuscular junction by the diffusion of acetylcholine across the?
The signal to excite a muscle cell involves the release of acetylcholine from the motor neuron into the synaptic cleft at the neuromuscular junction. Acetylcholine diffuses across the synaptic cleft and binds to receptors on the muscle cell membrane, leading to depolarization and muscle contraction. This process is crucial for transmitting signals from the nervous system to the muscle for movement.
When acetylcholine diffuses across the synaptic cleft and binds to receptors on the folded sarcolemma it initaly causes what channels to open in the sarcolemma?
Acetylcholine binding causes nicotinic acetylcholine receptors on the folded sarcolemma to open, allowing the influx of sodium ions into the muscle cell. This initiates an action potential that propagates along the sarcolemma and into the T-tubules, triggering muscle contraction.
How is acetylcholine (ACh) removed from the synaptic cleft?
Acetylcholine is degraded by acetylcholinesterase
When an action potential arrives at the neuromuscular junction the most immediate response?
is the release of acetylcholine from the motor neuron into the synaptic cleft.
What destroy acetylcholine?
Acetylcholinesterase is an enzyme that breaks down acetylcholine into choline and acetate. Certain toxins, such as organophosphates and nerve agents, can also inhibit acetylcholinesterase activity, leading to an accumulation of acetylcholine in the synaptic cleft.
The signal to excite a muscle cell must cross the neuromuscular junction by the diffusion of acetylcholine across the?
The signal to excite a muscle cell involves the release of acetylcholine from the motor neuron into the synaptic cleft at the neuromuscular junction. Acetylcholine diffuses across the synaptic cleft and binds to receptors on the muscle cell membrane, leading to depolarization and muscle contraction. This process is crucial for transmitting signals from the nervous system to the muscle for movement.
When acetylcholine diffuses across the synaptic cleft and binds to receptors on the folded sarcolemma it initaly causes what channels to open in the sarcolemma?
Acetylcholine binding causes nicotinic acetylcholine receptors on the folded sarcolemma to open, allowing the influx of sodium ions into the muscle cell. This initiates an action potential that propagates along the sarcolemma and into the T-tubules, triggering muscle contraction.
What is the substance released into the synaptic cleft?
Neurotransmitters are the substances released into the synaptic cleft. They are chemical messengers that transmit signals across the synapse from one neuron to another.
What is the normal sequence of events that occur during synaptic transmission at a motor end plate?
1. Nerve impulse reaches synaptic terminal. 2. Synaptic vesicles move to and merge with the presynaptic cell membrane of the motor neuron. 3. Acetylcholine is released into and diffuses across the synaptic cleft. 4. Acetylcholine binds to receptors on the postsynaptic cell membrane of the muscle fiber.
How is acetylcholine (ACh) removed from the synaptic cleft?
Acetylcholine is degraded by acetylcholinesterase
When an action potential arrives at the neuromuscular junction the most immediate response?
is the release of acetylcholine from the motor neuron into the synaptic cleft.
Acetylcholine in the synaptic cleft is broken down by?
Acetylcholine in the synaptic cleft is broken down by the enzyme acetylcholinesterase. This enzyme rapidly hydrolyzes acetylcholine into choline and acetate, terminating the signal transmission at the synapse.
What are the names of some common neurotransmitters?
Acetylcholine or aka ACH is the neurotransmitter that is released from the axon terminal to through the neuromuscular junction across the synaptic cleft which binds to the ACH receptors on the end motor plate of the Sarcolema.
Which structure contains vesicles with acetylcholine?
Synaptic vesicles in the axon terminals of neurons contain acetylcholine. Acetylcholine is a neurotransmitter that is released from these vesicles into the synaptic cleft to transmit signals to target cells or other neurons.
What is the ion needed to initiate the release of acetylcholine into the synaptic cleft called?
The ion needed to initiate the release of acetylcholine into the synaptic cleft is calcium (Ca2+). When an action potential reaches the presynaptic terminal, it causes voltage-gated calcium channels to open, allowing calcium to enter and trigger the release of acetylcholine-containing vesicles.
How is acetylcholine (ACh) removed from the synaptic cleft?
Acetylcholine (ACh) is removed from the synaptic cleft through a process called enzymatic degradation. The enzyme acetylcholinesterase breaks down ACh into its components, acetate and choline, which are then taken back up into the presynaptic neuron for recycling or further processing.
What most directly causes synaptic vesicles to release acetylcholine into the synaptic cleft?
The entry of calcium ions into the presynaptic terminal triggers the fusion of synaptic vesicles containing acetylcholine with the cell membrane, leading to the release of acetylcholine into the synaptic cleft. This process is known as calcium-dependent exocytosis and is a key mechanism for neurotransmitter release at synapses.
