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Extracellular matrix (ECM) coating is found on the outside of various tissues and organs in multicellular organisms. It provides structural and biochemical support to surrounding cells, facilitating communication and influencing cell behavior. In particular, ECM is prevalent in connective tissues, including cartilage, bone, and tendons, as well as in the basement membranes of epithelial tissues. This coating is crucial for maintaining tissue integrity and regulating cellular functions.

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