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Norepinephrine is primarily broken down by the enzyme monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) in the liver and other tissues. MAO oxidizes norepinephrine into its metabolite, dihydroxyphenylglycol (DHPG), while COMT methylates norepinephrine into normetanephrine.

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1y ago

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