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The three organism systems that work together to keep your body cool by perspiring are the integumentary system, the nervous system, and the endocrine system. The integumentary system, which includes the skin and sweat glands, produces sweat. The nervous system detects changes in body temperature and signals the sweat glands to activate. The endocrine system regulates hormones that can influence sweating and overall metabolism, further assisting in temperature regulation.

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