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Virtually all of the protein or amino acid-based hormones exert their effects through intracellular second messengers

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What type of hormone does NOT require a messenger to move it across the cell membrane?

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First messengers may not physically cross the phospholipid bilayer cell membrane to initiate changes within the cell directly and so require a secondary messenger. Second messengers may be coupled downstream to multi-cyclic kinase cascades to greatly amplify the strength of the original first messenger signal.Calcium ions are one type of second messengers and are responsible for many important physiological functions including muscle contraction, fertilization and neurotransmitter release.cAMP is also a second messenger.First messengers may not physically cross the phospholipid bilayer cell membrane to initiate changes within the cell directly and so require a secondary messenger.


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