Which type of joint would be most affected by Lyme disease?

Answer 1

The most affected joints would be the larger joints. Examples: the shoulder, the knees, elbows, and sometimes the hips.
In my case, my hips, knees and wrists are the main ones, yet every joint is affected just not as much as those
Joint inflammation in the knees and other large joints.

Lyme Arthritis usually affects the knees. In a minority of patients arthritis can occur in other joints, including the ankles, elbows, wrist, hips, and shoulders. Pain is often mild or moderate, usually with swelling at the involved joint. Baker's cysts may form and rupture. In some cases joint erosion occurs.

http://www.nlm.nih.gov/medlineplus/ency/article/000625.htm

http://en.wikipedia.org/wiki/Lyme_disease

Answer 2

Lyme disease can affect multiple joints, but it most commonly affects the large joints such as the knee. Lyme arthritis typically presents as a red, swollen, and painful joint, commonly the knee, due to inflammation caused by the bacterium Borrelia burgdorferi. Early diagnosis and treatment are important to prevent long-term joint damage.