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The term "animalcules" was coined by the Dutch scientist Antonie van Leeuwenhoek in the late 17th century. He used it to describe the microscopic organisms he observed in water, dental plaque, and other substances using his handcrafted microscopes. Van Leeuwenhoek's discoveries were pivotal in the early study of microbiology, revealing a previously unseen world of tiny life forms.

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