Best Answer

to make the solution basic enough so that NH be prepared for Fmoc protection

User Avatar

Wiki User

โˆ™ 2014-03-30 11:46:25
This answer is:
User Avatar
Study guides


20 cards

How does a buffer work

What happens in a neutralization reaction

What is a conjugate acid-base pair

Why is water considered to be neutral

See all cards
961 Reviews

Add your answer:

Earn +20 pts
Q: Why do you add sodium carbonate solution for Fmoc ptotection?
Write your answer...
Still have questions?
magnify glass
Continue Learning about Natural Sciences
Related questions

What Fmoc PNA Monomers do we already know?

[object Object]

What is the role of DIPEA in peptide synthesis?

DIPEA is tertiary amine used as base, but poor nucleophile. central N atom is surrounded by the two isopropyl groups and has only space to accept the hydrogen atom. Coupling of peptides occurs at slightly basic pH. HBTU converts Fmoc amino acid into active ester in presence of one equivalent of base. For this purpose DIPEA is routinely used.

What should be taken into consideration in gmp peptide synthesis?

in gmp peptide synthesis, there are a lot to consider:Synthesis strategy (i.e. solid phase peptide synthesis, solution phase peptide synthesis)• Protection groups (i.e. Boc-, Fmoc - processes)• Purification strategy (i.e. preparative HPLC, conventional chromatography, ion exchange, gel chromatography, counter-current distribution)• Flexibility and upscaling• Special customer request (i.e. dedicated production lines)• Special equipment (i.e. enzymatic unit, electrolysis unit)For finished dosage forms intended for clinical trials or commercial supply, CreativePep offers for its Active Pharmaceutical Ingredients (APIs)• Formulation development• Compatibility studies• Sterile filling in cooperation with partners• Release• Stability studiesI got this info from the website of Creative Peptides ( Hope it's useful for you.

What is the label for phosphate?

Abbreviations A: Adenosine Ade: Adenine ATP: Adenosine triphosphate B: Nucleobase BMF4TPA: Bis(difluoromethylene)triphosphoric acid BMT: Bismethylene triphosphate Boc: Tert-Butyloxycarbonyl Bop: Bis(2-oxo-3-oxazolidinyl)phosphinic BP : Protected nucleobase BTT: 5-Benzylthio-1-H-tetrazole C: Cytosine CDI: Carbodiimidazole CE: ฮฒ-Cyanoethyl CEM: Cyanooxymethyl CMPT: N-(cyanomethyl)pyrrolidinium triflate CPG: Controlled pore glass CTP: Cytidine triphosphate Cyt: Cytidine DBU: 1,8-Diazabicyclo[5.4.0]undec-7-ene DCA: Dichloroacetic acid DCI: 4,5-Dicyanoimidazole DEAE: Diethylaminoethyl DIAD: Diisopropyl azodicarboxylate DIPEA: Diisopropylethylamine DMAN: 1,8-Bis-(dimethylamino)naphthalene DMF: N,N-dimethylformamide DMS: Dimethylsulfide DMTr: 4,4โ€ฒ-Dimethoyxltrityl DTD: N,N-dimethylthiuram disulfide EC50 : Half maximal effective concentration EDC/EDCI: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide ETT: 5-(Ethylthio)-1H-tetrazole Fm: 9-Fluorenylmethyl Fmoc: Fluorenylmethyloxycarbonyl G: Guanosine Gua: Guanine IC50 : Half maximal inhibitor concentration IEX-HPLC: Ion-exchange high performance liquid chromatography KHMDS: Hexamethyldisilazide LTMPA: Lithium 2,2,6,6-tetramethylpiperidine amide NHS: N-hydroxysuccinimide NMP: Nucleoside monophosphate Npn : Nucleoside polyphosphate NpnN: Dinucleotide polyphosphate NPP: Nucleotide pyrophosphatase/phosphodiesterase Ns: Nosyl NTP: Nucleoside triphosphate NTP: Nucleoside triphosphate Nuc: Nucleotide or nucleoside ODN: Oligodeoxynucleotides ORN: Oligoribonucleotide OTP: Oxathiaphospholane PEP: Phosphoenolpyruvate Pip: Piperidine PK: Pyruvate dinase ppGpp: Guanosin-3โ€ฒ,5โ€ฒ-bispyrophosphate ppp: RNA 5โ€ฒ-triphosphate RNAs PRR: Pattern recognition receptors Py: Pyridine RP18: Reverse phase C18 RSH: RelA-SpoT homolog SAX: Strong anion exchange T: Thymine TBAF: Tetrabutylammonium fluoride TBHP: tert-Butylhydroperoxide TBS: tert-Butyldimethylsilyl TEA: Triethylamine TEAB: Triethylammonium bicarbonate Tf: Trifluoromethylsulfonyl THF: Tetrahydrofuran Thy: Thymidine TMS: Trimethylsilyl Tr: 2,4,6-Triisopropylbenzenesulfonyl Ts: p-Toluenesulfonyl U: Uridine Ura: Uracil UTP: Uridine triphosphate

People also asked