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AnswerIn some cases it's not. Many organisms get along quite well without O2. And that (for a short time) includes most (not all) of the cells of your body. This form of respiration is called anaerobic respiration, of which there are two forms (alcohol and lactic acid).

However, all the multicellular animal organisms that we know share the "Kreb's cycle" via mitochondria that need oxygen for cellular respiration, because your mitochondria (or their genes) can't utilize any other oxidizers.

Some extremophiles (bacteria in cave ecosystems) can use other oxidizers (like nitrogen or sulfur) due to the lack of oxygen in their environment. Both nitrogen and sulfur are similarly strong oxidizers to pull electrons from the electron transport chain.

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