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Because detergent is a phospholipid-like molecule, meaning the the head is hyrophillic (attracted to water) and the tail is hyrdophobic (doesn't like water). Water is highly polar so when you add detergent the heads will attract to the water molecule. However the tails will try to stick to something that isn't water. (like your hands) So when the heads get pulled they pull whatever the tails are attached to aswell, so you'll notice sometimes that your hands become dry.

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